N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine

Base Information

• Chemical Name: N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine
• CAS No.: 1607589-97-8
• Molecular Formula: C₁₆H₂₃N₃O₂S₂
• Molecular Weight: 353.51

Synonyms:N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine

Chemical Property of N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine

Chemical Property:

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Technology Process of N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine

There total 7 articles about N₇-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2) → N7-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine (1607589-97-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; isopropyl alcohol;

Reference yield:

N-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}-6-nitrothieno[3,2-b]pyridin-7-amine (1607589-96-7) → N7-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine (1607589-97-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

7-chloro-6-nitrothieno[3,2-b]pyridine (110651-92-8) → N7-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}thieno[3,2-b]pyridine-6,7-diamine (1607589-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; isopropyl alcohol;

upstream raw materials:

7-chloro-6-nitrothieno[3,2-b]pyridine

thieno[3,2-b]pyridin-7-ol

N-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}-6-nitrothieno[3,2-b]pyridin-7-amine

6-nitrothieno[3,2-b]pyridin-7-ol

Downstream raw materials:

(1R)-1-(1-{trans-4-[2-(methylsulfonyl)ethyl]cyclohexyl}-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl)ethanol

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