Technology Process of (2S,3R)-2,3-bis<(benzyloxy)methoxy>-2-methylpentanol
There total 4 articles about (2S,3R)-2,3-bis<(benzyloxy)methoxy>-2-methylpentanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 40 h / Ambient temperature
2: 87 percent / MeLi / diethyl ether / 0.5 h / 0 °C
With
Proton Sponge; methyllithium; sodium iodide;
In
1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/ja00090a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Ti(O-i-Pr)4, t-BuOOH, 4A-molecular sieves, diisopropyl D-tartarate / 1.) CH2Cl2, 2,2,4-trimethylpentane, -20 deg C, 30 min, 2.) CH2Cl2, 2,2,4-trimethylpentane, -20 deg C, 11 h
2: 63 percent / Ti(O-i-Pr)4 / CH2Cl2 / 40 h / Ambient temperature
3: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 40 h / Ambient temperature
4: 87 percent / MeLi / diethyl ether / 0.5 h / 0 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; Proton Sponge; 4 A molecular sieve; methyllithium; D-(-)-diisopropyl tartrate; sodium iodide;
In
1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1021/ja00090a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 63 percent / Ti(O-i-Pr)4 / CH2Cl2 / 40 h / Ambient temperature
2: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 40 h / Ambient temperature
3: 87 percent / MeLi / diethyl ether / 0.5 h / 0 °C
With
titanium(IV) isopropylate; Proton Sponge; methyllithium; sodium iodide;
In
1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1021/ja00090a016
