1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453853-89-8
Molecular Formula:C₃₀H₄₀ClFN₄O₃Si
Molecular Weight:587.21
Hs Code.:

Synonyms:1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of 1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of 1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 8 articles about 1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1453855-02-1
3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl methanesulfonate

: 1453851-89-2
4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453853-89-8
1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 95 ℃; for 2h; Microwave irradiation;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453853-89-8
1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: 1H-imidazole / dichloromethane / 20 °C

4: triethylamine / dichloromethane / 20 °C

5: tetra-(n-butyl)ammonium iodide; potassium tert-butylate / tetrahydrofuran / 2 h / 95 °C / Microwave irradiation

With 1H-imidazole; sodium tetrahydroborate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 1453853-83-2
4-(4-chloro-3-fluorophenyl)-4-hydroxybutan-2-one

: 1453853-89-8
1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)butyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: 1H-imidazole / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: tetra-(n-butyl)ammonium iodide; potassium tert-butylate / tetrahydrofuran / 2 h / 95 °C / Microwave irradiation

With 1H-imidazole; sodium tetrahydroborate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;