Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Base Information

Chemical Name:Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester
CAS No.:1053733-28-0
Molecular Formula:C₆₄H₆₈N₃O₁₃P
Molecular Weight:1118.23
Hs Code.:

Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Synonyms:Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Suppliers and Price of Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

There total 18 articles about Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 158215-61-3
2-O-Allyl-3,4,5-tri-O-benzyl-1-O-(dibenzylphosphono)-6-(6-O-acetyl-2-azido-3,4-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-D-myo-inositol

: 1053733-28-0
Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Guidance literature:: With ammonia; In tetrahydrofuran; methanol; at 0 ℃; for 68h;
DOI:10.1021/jo00090a035

Reference yield:

: 2595-06-4,18685-19-3,40653-13-2,40653-30-3,67583-56-6,68027-26-9,73111-52-1
methyl 2,3,4-tri-O-benzyl-6-O-trityl-α-D-glucopyranoside

: 1053733-28-0
Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: p-TsOH / methanol; CH₂Cl₂ / 12 h / Ambient temperature

2: 74 percent / pyridine, Ph₃P, CI₄ / 12 h / Ambient temperature

3: 95percent NaH / dimethylformamide / 20 h

4: 1.) aq. HgCl₂, 2.) MsCl, DMAP, pyridine / 1.) acetone, 100 deg C, 1.5 h, 2.) r.t., 4 h

5: 1.) CeCl₃*7H₂O, 2.) NaBH₄ / 1.) MeOH, -50 deg C, 10 min, 2.) -50 deg C, 5 h

6: 55percent m-CPBA / CH₂Cl₂ / 24 h / Ambient temperature

7: 75 percent / BF₃*Et₂O / CH₂Cl₂ / 3.5 h / Ambient temperature

8: 85 percent / Bu₂SnO, 3 Angstroem molecular sieves, Bu₄NBr / acetonitrile / 5 h / 80 °C

9: 89 percent / PCC / CH₂Cl₂ / 13 h / Ambient temperature

10: 1.) (R)-Alpine hydride, 2.) 3 M aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, -90 deg C, 30 min, 2.) O deg C, 30 min

11: 1.) tetrazole, 2.) aq. NaIO₄ / 2.) RuCl₃*3H₂O / 1.) MeCN, CH₂Cl₂, r.t., 1.5 h, 2.) 0 deg C, 0.5 h

12: 84 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

13: 65 percent / CF₃SO₂SiMe₃ / CH₂Cl₂ / 1.) -20 deg C, 2 h, 2.) -20 deg C to r.t., 0.5 h

14: 56 percent / NH₃ / tetrahydrofuran; methanol / 68 h / 0 °C

With pyridine; 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; cerium(III) chloride; R-Alpine-Hydride; carbon tetraiodide; 3 A molecular sieve; boron trifluoride diethyl etherate; tetrabutylammomium bromide; ammonia; dihydrogen peroxide; sodium hydride; di(n-butyl)tin oxide; trimethyl((trifluoromethyl)sulfonyl)silane; toluene-4-sulfonic acid; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; mercury dichloride; ruthenium trichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00090a035

Reference yield:

: 53008-65-4,641635-63-4
methyl 2,3,4-tri-O-benzyl-D-glucopyranoside

: 1053733-28-0
Phosphoric acid (1R,2R,3R,4R,5S,6R)-2-allyloxy-6-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3,4,5-tris-benzyloxy-cyclohexyl ester dibenzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 74 percent / pyridine, Ph₃P, CI₄ / 12 h / Ambient temperature

2: 95percent NaH / dimethylformamide / 20 h

3: 1.) aq. HgCl₂, 2.) MsCl, DMAP, pyridine / 1.) acetone, 100 deg C, 1.5 h, 2.) r.t., 4 h

4: 1.) CeCl₃*7H₂O, 2.) NaBH₄ / 1.) MeOH, -50 deg C, 10 min, 2.) -50 deg C, 5 h

5: 55percent m-CPBA / CH₂Cl₂ / 24 h / Ambient temperature

6: 75 percent / BF₃*Et₂O / CH₂Cl₂ / 3.5 h / Ambient temperature

7: 85 percent / Bu₂SnO, 3 Angstroem molecular sieves, Bu₄NBr / acetonitrile / 5 h / 80 °C

8: 89 percent / PCC / CH₂Cl₂ / 13 h / Ambient temperature

9: 1.) (R)-Alpine hydride, 2.) 3 M aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, -90 deg C, 30 min, 2.) O deg C, 30 min

10: 1.) tetrazole, 2.) aq. NaIO₄ / 2.) RuCl₃*3H₂O / 1.) MeCN, CH₂Cl₂, r.t., 1.5 h, 2.) 0 deg C, 0.5 h

11: 84 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

12: 65 percent / CF₃SO₂SiMe₃ / CH₂Cl₂ / 1.) -20 deg C, 2 h, 2.) -20 deg C to r.t., 0.5 h

13: 56 percent / NH₃ / tetrahydrofuran; methanol / 68 h / 0 °C

With pyridine; 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; cerium(III) chloride; R-Alpine-Hydride; carbon tetraiodide; 3 A molecular sieve; boron trifluoride diethyl etherate; tetrabutylammomium bromide; ammonia; dihydrogen peroxide; sodium hydride; di(n-butyl)tin oxide; trimethyl((trifluoromethyl)sulfonyl)silane; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; mercury dichloride; ruthenium trichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00090a035