methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

Base Information

Chemical Name:methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate
CAS No.:767288-21-1
Molecular Formula:C₁₆H₂₂BrNO₄S
Molecular Weight:404.325
Hs Code.:

Synonyms:methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

Chemical Property:

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Technology Process of methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

There total 4 articles about methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: methyl (S)-6-aza-8-hydroxy-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

: 767288-21-1
methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

: 903516-12-1
methyl (7S)-(2Z)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1021/jo060495w

Reference yield:

: 767288-12-0
(5S)-4-aza-1-hydroxy-5-methyl-7-oxa-4-(p-toluenesulfonyl)cycloheptane

: 767288-21-1
methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: benzoic acid / toluene / 90 °C

2: Ph₃P; CBr₄ / CH₂Cl₂ / 25 °C

With carbon tetrabromide; triphenylphosphine; benzoic acid; In dichloromethane; toluene; 1: Wittig reaction;
DOI:10.1039/b409714a

Reference yield:

: 767288-33-5
N-(3,3-dimethoxy-propyl)-N-(2-hydroxy-1-methyl-ethyl)-4-methyl-benzenesulfonamide

: 767288-21-1
methyl (2E,7S)-6-aza-8-bromo-7-methyl-6-(p-toluenesulfonyl)oct-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / tetrahydrofuran / 25 °C

2: benzoic acid / toluene / 90 °C

3: Ph₃P; CBr₄ / CH₂Cl₂ / 25 °C

With hydrogenchloride; carbon tetrabromide; triphenylphosphine; benzoic acid; In tetrahydrofuran; dichloromethane; toluene; 2: Wittig reaction;
DOI:10.1039/b409714a