Technology Process of 3-[4-Ethoxy-2,6-dimethoxyphenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine
There total 10 articles about 3-[4-Ethoxy-2,6-dimethoxyphenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C24H33N3O6S;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Tetrahydro-4H-pyran-4-one;
With
sodium tris(acetoxy)borohydride; acetic acid;
In
tetrahydrofuran;
at 20 ℃;
for 11.5h;
With
water; sodium hydrogencarbonate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydroxide; water / ethanol / 2 h / 20 - 80 °C
1.2: Cooling with ice
1.3: 1.5 h / 60 °C
2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 20 °C / Cooling with ice
2.2: Cooling with ice
2.3: 5 h / 20 °C / 760.05 Torr
3.1: triethylamine / dichloromethane / 11 h / 20 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -78 °C
4.2: 2 h
5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water / 2.58 h / 110 °C / Reflux
6.1: potassium carbonate / N,N-dimethyl-formamide / 16.17 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
8.2: 11.5 h / 20 °C
With
hydrogenchloride; n-butyllithium; water; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water / 2.58 h / 110 °C / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 16.17 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
4.2: 11.5 h / 20 °C
With
sodium hydride; potassium carbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
