N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid

Base Information

• Chemical Name: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid
• CAS No.: 112888-03-6
• Molecular Formula: C₂₃H₂₄N₄O₇
• Molecular Weight: 468.466

Synonyms:N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid

Chemical Property of N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid

Chemical Property:

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Technology Process of N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid

There total 5 articles about N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-2-{4-[(2,4-Dimethoxy-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid diethyl ester (118111-78-7) → N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid (112888-03-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 60 ℃; for 14.5h;

DOI:10.1021/jm00123a010

Reference yield:

diethyl N-<4-(methylamino)benzoyl>-L-glutamate (2378-95-2) → N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid (112888-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / 2,6-lutidine / dimethylformamide / 70 °C

2: 83 percent / 1 N aq. NaOH / ethanol; H₂O / 14.5 h / 60 °C

With 2,6-dimethylpyridine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a010

Reference yield:

6-(Bromomethyl)-2,4-dimethoxyquinazoline (112888-62-7) → N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid (112888-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / 2,6-lutidine / dimethylformamide / 70 °C

2: 83 percent / 1 N aq. NaOH / ethanol; H₂O / 14.5 h / 60 °C

With 2,6-dimethylpyridine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a010

upstream raw materials:

(S)-2-{4-[(2,4-Dimethoxy-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

diethyl N-<4-(methylamino)benzoyl>-L-glutamate

6-(Bromomethyl)-2,4-dimethoxyquinazoline

2,4-Dimethoxy-6-methylquinazoline

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