2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

Base Information

Chemical Name:2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione
CAS No.:688349-21-5
Molecular Formula:C₃₁H₂₇NO₆S
Molecular Weight:541.624
Hs Code.:

Synonyms:2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

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Chemical Property of 2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

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Technology Process of 2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

There total 8 articles about 2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 129800-98-2
2-(bromomethyl)-3-(phenylsulfonyl)-1-propene

: 688349-15-7
2-[(S)-1-((R)-6-Oxo-3,6-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

: 688349-21-5
2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1055/s-2004-815439

Reference yield:

: 136465-80-0
2(S)-[2-phenyl-1(S)-phthalimidoethyl]oxirane

: 688349-21-5
2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1: n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 °C

2: TBAF / tetrahydrofuran / 0 °C

3: Et₃N / tetrahydrofuran / 20 °C

4: tetrahydrofuran / -78 - 20 °C

5: aq. HCl

6: H₂ / Lindlar's catalyst / ethyl acetate

7: PTSA / toluene / Heating

8: 77 percent / LDA / tetrahydrofuran / -78 °C

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1055/s-2004-815439

Reference yield:

: 688349-11-3
2-((1S,2R)-1-Benzyl-2-hydroxy-pent-4-ynyl)-isoindole-1,3-dione

: 688349-21-5
2-[(S)-1-((3R,4aS,5R,7aS)-5-Benzenesulfonyl-6-methylene-1-oxo-octahydro-cyclopenta[c]pyran-3-yl)-2-phenyl-ethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 20 °C

2: tetrahydrofuran / -78 - 20 °C

3: aq. HCl

4: H₂ / Lindlar's catalyst / ethyl acetate

5: PTSA / toluene / Heating

6: 77 percent / LDA / tetrahydrofuran / -78 °C

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1055/s-2004-815439