2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Base Information

Chemical Name:2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
CAS No.:1616293-25-4
Molecular Formula:C₁₈H₁₈F₂N₂O₂
Molecular Weight:332.35
Hs Code.:

Synonyms:2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Chemical Property of 2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Technology Process of 2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

There total 9 articles about 2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 348-57-2
2,4-difluorobromobenzene

: 1616293-24-3
2-butoxy-7,8-dihydro-1,6-naphthyridin-5(6H)-one

: 1616293-25-4
2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; for 6h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm500259z

Reference yield:

: 1226898-93-6
2-chloro-7.8-dihydro-6H-[1.6]naphthyridin-5-one

: 1616293-25-4
2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: copper(l) iodide; N,N`-dimethylethylenediamine; potassium carbonate / toluene / 6 h / 110 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; potassium tert-butylate; potassium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm500259z

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1616293-25-4
2-butoxy-6-(2,4-difluorophenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / 48 h / 80 °C / Inert atmosphere

2.1: thionyl chloride / 5 h / 80 °C / Inert atmosphere

3.1: 1 h / 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

5.1: ammonia / methanol / 24 h / 0 °C / Inert atmosphere

6.1: acetic acid; hydrogen bromide / 16 h / 60 °C / Inert atmosphere

7.1: trichlorophosphate / 8 h / 100 °C / Inert atmosphere

8.1: potassium tert-butylate / N,N-dimethyl-formamide / Inert atmosphere

8.2: 100 °C / Inert atmosphere

9.1: copper(l) iodide; N,N`-dimethylethylenediamine; potassium carbonate / toluene / 6 h / 110 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; 2,6-di-tert-butyl-4-methyl-phenol; potassium tert-butylate; ammonia; hydrogen bromide; potassium carbonate; acetic acid; N,N`-dimethylethylenediamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm500259z