2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

Base Information

Chemical Name:2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride
CAS No.:634903-73-4
Molecular Formula:C₂₅H₂₇N₃O₃S*ClH
Molecular Weight:486.035
Hs Code.:

Synonyms:2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

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Chemical Property of 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

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Technology Process of 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

There total 7 articles about 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate

: 634903-73-4
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide

: 634903-73-4
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane; water

2.1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 80 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol

4.1: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

4.2: 18 h / 20 °C

5.1: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide hydrochloride

: 634903-73-4
2-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)-benzyl methylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 80 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol

3.1: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide); water;