(2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol

Base Information

• Chemical Name: (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol
• CAS No.: 1602924-03-7
• Molecular Formula: C₁₅H₁₇F₆NO
• Molecular Weight: 341.296

Synonyms:(2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol

Chemical Property of (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol

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Technology Process of (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol

There total 1 articles about (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(m-trifluoromethylphenyl)-piperidine hydrochloride (64321-43-3) + (S)-2-trifluoromethyl-oxirane (130025-34-2) → (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol (1602924-03-7)

Guidance literature:

3-(m-trifluoromethylphenyl)-piperidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.166667h; Inert atmosphere;

(S)-2-trifluoromethyl-oxirane; In acetonitrile; for 3h; Inert atmosphere;

Reference yield: 45.0%

(2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol (1602924-03-7) + 3-chloro-4-fluorophenyl isocyanate (50529-33-4) → (3-chloro-4-fluoro-phenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester (1602923-67-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 21.0%

6-chloropyridin-3-yl isocyanate (125117-96-6) + (2S)-1,1,1-trifluoro-3-(3-(3-(trifluoromethyl)phenyl)-piperidin-1-yl)propan-2-ol (1602924-03-7) → (6-chloropyridin-3-yl)-carbamic acid (S)-2,2,2-trifluoro-1-[3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester (1602923-70-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

3-(m-trifluoromethylphenyl)-piperidine hydrochloride

(S)-2-trifluoromethyl-oxirane

Downstream raw materials:

(4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester hydrochloride

(4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[(R)-3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester

(4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[(R)-3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester hydrochloride

(5-chloropyridin-2-yl)-carbamic acid (S)-2,2,2-trifluoro-1-[(R)-3-(3-trifluoromethylphenyl)-piperidin-1-ylmethyl]-ethyl ester hydrochloride

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