N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

Base Information

Chemical Name:N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine
CAS No.:134363-54-5
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

Synonyms:N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

Chemical Property:

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Technology Process of N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

There total 4 articles about N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134363-60-3
N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine methyl ester

: 134363-54-5
N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 0 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00056a005

Reference yield:

: 7479-01-8
O-methyl-L-tyrosine methyl ester hydrochloride

: 134363-54-5
N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / N-methylmorpholine, DMAP, DMF / CH₂Cl₂ / 36 h / Ambient temperature

2: 87 percent / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h

3: 1.97 g / CH₂Cl₂ / 16 h / Ambient temperature

4: aq. LiOH*H₂O / dioxane / 1.5 h / 0 °C

With 4-methyl-morpholine; dmap; lithium hydroxide; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm00056a005

Reference yield:

: 134363-80-7
N-<3-<(benzyloxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine methyl ester

: 134363-54-5
N-<3-<(tert-butoxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h

2: 1.97 g / CH₂Cl₂ / 16 h / Ambient temperature

3: aq. LiOH*H₂O / dioxane / 1.5 h / 0 °C

With lithium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm00056a005