(S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Base Information

• Chemical Name: (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester
• CAS No.: 865692-01-9
• Molecular Formula: C₂₉H₃₁F₃N₂O₉
• Molecular Weight: 608.568

Synonyms:(S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Chemical Property of (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

There total 7 articles about (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-4-trifluoromethanesulfonyloxy-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (865691-99-2) → (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (865692-01-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

DOI:10.1021/jo050363n

Reference yield:

(S)-2-(2,2,2-trifluoro-acetylamino)-pent-4-ynoic acid methyl ester (865691-95-8) → (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (865692-01-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / diethyl ether / 0 - 20 °C

1.2: acetyl bromide / diethyl ether; CH₂Cl₂ / 60 °C

1.3: 256 mg / tetrahydrofuran / 60 °C

2.1: 75 percent / DMAP; Et₃N / CH₂Cl₂ / 10 h / 20 °C

3.1: Zn; 1,2-dibromoethane; chlorotrimethylsilyl chloride / tetrahydrofuran; N,N-dimethyl-acetamide / 1 h / sonnication

3.2: 66 percent / Pd₂(dba)2*CHCl₃; tri-o-tolylphosphine / tetrahydrofuran; N,N-dimethyl-acetamide / 2 h / 55 °C

4.1: 86 percent / TBAF / tetrahydrofuran

5.1: 60 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

6.1: 95 percent / triethylamine; formic acid; dppf / Pd(OAc₀₂ / dimethylformamide / 6 h / 70 °C

With pyridine; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; chlorotrimethylsilyl chloride; tetrabutyl ammonium fluoride; sodium hydride; ethylene dibromide; triethylamine; zinc; palladium diacetate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jo050363n

Reference yield:

(S)-3-[4-hydroxy-7-(4-iodo-phenoxy)-benzofuran-5-yl]-2-(2,2,2-trifluoroacetylamino)-propionic acid methyl ester (865692-05-3) → (S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (865692-01-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 75 percent / DMAP; Et₃N / CH₂Cl₂ / 10 h / 20 °C

2.1: Zn; 1,2-dibromoethane; chlorotrimethylsilyl chloride / tetrahydrofuran; N,N-dimethyl-acetamide / 1 h / sonnication

2.2: 66 percent / Pd₂(dba)2*CHCl₃; tri-o-tolylphosphine / tetrahydrofuran; N,N-dimethyl-acetamide / 2 h / 55 °C

3.1: 86 percent / TBAF / tetrahydrofuran

4.1: 60 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

5.1: 95 percent / triethylamine; formic acid; dppf / Pd(OAc₀₂ / dimethylformamide / 6 h / 70 °C

With pyridine; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; chlorotrimethylsilyl chloride; tetrabutyl ammonium fluoride; ethylene dibromide; triethylamine; zinc; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jo050363n

upstream raw materials:

(S)-3-{7-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-4-trifluoromethanesulfonyloxy-benzofuran-5-yl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

(S)-2-(2,2,2-trifluoro-acetylamino)-pent-4-ynoic acid methyl ester

(S)-3-[4-hydroxy-7-(4-iodo-phenoxy)-benzofuran-5-yl]-2-(2,2,2-trifluoroacetylamino)-propionic acid methyl ester

(S)-3-[4-tert-butyl-dimethyl-silanyloxy-7-(4-iodo-phenoxy)-benzofuran-5-yl]-2-(2,2,2-trifluoroacetylamino)-propionic acid methyl ester

Downstream raw materials:

(S,S)-isodityrosine bis hydrochloride

(S)-3-{3-[4-((S)-2-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-4-hydroxy-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

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