ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate
CAS No.:1176869-91-2
Molecular Formula:C₂₈H₂₉ClO₆
Molecular Weight:496.988
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

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Chemical Property of ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

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Technology Process of ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

There total 3 articles about ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7065-46-5
3,3-dimethylbutanoic acid chloride

: 1176869-89-8
ethyl 5-(4-chlorophenyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

: 1176869-91-2
ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

Guidance literature:: ethyl 5-(4-chlorophenyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; In tetrahydrofuran; at -40 ℃; for 0.416667h; Inert atmosphere;

With copper(I) cyanide*lithium chloride; zinc(II) chloride; In tetrahydrofuran; at -40 ℃; for 0.5h; Inert atmosphere;

3,3-dimethylbutanoic acid chloride; In tetrahydrofuran; at -40 - 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/b907330b

Reference yield:

: 1176869-82-1
ethyl 4-(2-(4-chlorophenyl)-5-(trimethylsilyl)furan-3-yl)benzoate

: 1176869-91-2
ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / -40 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex / tetrahydrofuran / -40 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; isopropylmagnesium bromide; In tetrahydrofuran;
DOI:10.1002/chem.201003657

Reference yield:

: 1176869-74-1
ethyl 4-(2-((4-methoxyphenyl)sulfinyl)-5-(trimethylsilyl)furan-3-yl)benzoate

: 1176869-91-2
ethyl 5-(4-chlorophenyl)-3-(3,3-dimethylbutanoyl)-4-[4-(ethoxycarbonyl)phenyl]-2-furoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / 2-methyl-THF / 1 h / -50 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

1.3: 2 h / 50 °C / Inert atmosphere

2.1: isopropylmagnesium bromide / tetrahydrofuran / -40 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

3.1: bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex / tetrahydrofuran / -40 °C / Inert atmosphere

3.2: 25 °C / Inert atmosphere

With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; isopropylmagnesium bromide; In tetrahydrofuran; 2-methyl-THF;
DOI:10.1002/chem.201003657