6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

Base Information

Chemical Name:6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide
CAS No.:172101-68-7
Molecular Formula:C₁₄H₁₄N₄OS₂
Molecular Weight:318.423
Hs Code.:

Synonyms:6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

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Chemical Property of 6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

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Technology Process of 6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

There total 5 articles about 6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 172101-67-6
2-<1-benzyl-5-cyano-2-(methylsulfanyl)imidazol-4-ylthio>acetamide

: 172101-68-7
6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

Guidance literature:: With sodium ethanolate; In ethanol; for 1h; Heating;
DOI:10.1016/0040-4020(95)00845-Y

Reference yield:

: 106848-43-5
1-benzyl-4-bromo-2-(methylsulfanyl)imidazole-5-carbaldehyde

: 172101-68-7
6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride, NaHCO₃ / ethanol; H₂O / Ambient temperature

2: 85 percent / acetic anhydride / 1 h / Heating

3: 1.) 1.5 mol dm^-3 BuLi, S₈ / 1.) hexane, THF, -100 deg C, 3 min; -80 deg C, 10 min, 2.) hexane, THF, to 10 deg C

4: 90 percent / NaOEt / ethanol / 1 h / Heating

With sulfur; n-butyllithium; hydroxylamine hydrochloride; sodium ethanolate; sodium hydrogencarbonate; In ethanol; water; acetic anhydride;
DOI:10.1016/0040-4020(95)00845-Y

Reference yield:

: 112517-31-4
1-benzyl-4,5-dibromo-2-(methylsulfanyl)imidazole

: 172101-68-7
6-amino-1-benzyl-2-(methylsulfanyl)thieno<2,3-d>imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1.54 mol dm^-3 BuLi, ZnI₂ / 1.) hexane, THF, 2 min; to RT 20 min, 2.) THF, hexane, 24 h, RT

2: 1.) 1.5 mol dm^-3 BuLi, S₈ / 1.) hexane, THF, -100 deg C, 3 min; -80 deg C, 10 min, 2.) hexane, THF, to 10 deg C

3: 90 percent / NaOEt / ethanol / 1 h / Heating

With sulfur; n-butyllithium; sodium ethanolate; zinc(II) iodide; In ethanol;
DOI:10.1016/0040-4020(95)00845-Y