methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate
CAS No.:857904-19-9
Molecular Formula:C₃₀H₄₄N₄O₆
Molecular Weight:556.703
Hs Code.:

Synonyms:methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Chemical Property of methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Technology Process of methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

There total 7 articles about methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.8%

: 872703-56-5
[(1S)-1-(N'-benzyl-hydrazinocarbonyl)-2,2-dimethyl-propyl]carbamic acid methyl ester

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 857904-19-9
methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: In isopropyl alcohol; for 16h; Reflux;

Reference yield:

: 857904-18-8
Tert-butyl (1S,2S)-1-benzyl-3-(1-benzylhydrazino)-2-hydroxypropylcarbamate

: 162537-11-3
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid

: 857904-19-9
methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield:

: 20859-02-3
L-tert-Leucine

: 857904-19-9
methyl (S)-1-(2-benzyl-2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 18 h / 60 °C / pH 8 - 9

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: isopropyl alcohol / 1.5 h / 20 °C

5.1: hydrogen; sodium formate / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

6.1: isopropyl alcohol / 16 h / Reflux

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; sodium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; ethyl acetate; isopropyl alcohol;