Technology Process of (R)-N-(benzoyl)-S-(isobutyl)cysteinylsulfone-methylazaalanine-nitrile
There total 3 articles about (R)-N-(benzoyl)-S-(isobutyl)cysteinylsulfone-methylazaalanine-nitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium acetate;
In
methanol;
at 20 ℃;
for 24h;
DOI:10.1021/jm300734k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium permanganate / water; acetic acid / 2.5 h / 20 °C
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C
2.2: 2 h / -25 - 20 °C
3.1: acetyl chloride / ethanol; ethyl acetate / 0.5 h / Cooling with ice
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
5.1: sodium acetate / methanol / 24 h / 20 °C
With
4-methyl-morpholine; potassium permanganate; sodium acetate; N-ethyl-N,N-diisopropylamine; acetyl chloride; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate;
DOI:10.1021/jm300734k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C
1.2: 2 h / -25 - 20 °C
2.1: acetyl chloride / ethanol; ethyl acetate / 0.5 h / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
4.1: sodium acetate / methanol / 24 h / 20 °C
With
4-methyl-morpholine; sodium acetate; N-ethyl-N,N-diisopropylamine; acetyl chloride; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
DOI:10.1021/jm300734k
