10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A

Base Information

• Chemical Name: 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A
• CAS No.: 717889-17-3
• Molecular Formula: C₃₈H₅₉N₃O₁₀
• Molecular Weight: 717.901
• Mol file: 717889-17-3.mol

Synonyms:10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A

Chemical Property of 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A

There total 7 articles about 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

11-amino-[11N-12O]-carbonyl-11-deshydroxy-10-desmethyl-10-methylene-6-O-methyl-3-oxo-descladinosyl-erythromycin (717889-14-0) + benzylamine (100-46-9) → 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O6-methyl-3-oxodescladinosylerythromycin A (717889-17-3)

Guidance literature:

In tetrahydrofuran; for 41h; Heating / reflux;

Reference yield:

C40H61N3O11 → 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O6-methyl-3-oxodescladinosylerythromycin A (717889-17-3)

Guidance literature:

With methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.02.041

Reference yield:

2'O-acetyl-11N,12O-cyclocarbamate-11-deshydroxy-10-desmethyl-O6-methyl-10-methylene-3-oxodescladinosylerythromycin A (717889-13-9) → 10-benzylaminometyl-10N,12O-cyclocarbamate-10-deshydroxy-10-desmethyl-O6-methyl-3-oxodescladinosylerythromycin A (717889-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 48 h / Reflux; Inert atmosphere

2: methanol / 20 °C / Inert atmosphere

With methanol; In tetrahydrofuran;

DOI:10.1016/j.bmc.2017.02.041

upstream raw materials:

11-amino-[11N-12O]-carbonyl-11-deshydroxy-10-desmethyl-10-methylene-6-O-methyl-3-oxo-descladinosyl-erythromycin

benzylamine

10-acetoxymethyl-2'O-acetyl-10,11-anhydro-10-desmethyl-O⁶-methyl-3-oxodescladinosylerythromycin A

2'O-acetyl-11N,12O-cyclocarbamate-11-deshydroxy-10-desmethyl-O⁶-methyl-10-methylene-3-oxodescladinosylerythromycin A