cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

Base Information

Chemical Name:cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide
CAS No.:740873-17-0
Molecular Formula:C₂₀H₃₄N₄O₂S
Molecular Weight:394.582
Hs Code.:

Synonyms:cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

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Chemical Property of cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

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Technology Process of cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

There total 5 articles about cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 896125-10-3
cyclohexanesulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

: 740873-17-0
cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In methanol; at -10 - 20 ℃;
DOI:10.1021/jm0508641

Reference yield:

: 54054-85-2
1-(3-nitrophenyl)piperazine

: 740873-17-0
cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / Et₃N / tetrahydrofuran / 48 h / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

3: 61 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 75 percent / SnCl₂; aq. HCl / methanol / -10 - 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0508641

Reference yield:

: 740873-01-2
{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}carbamic acid tert-butyl ester

: 740873-17-0
cyclohexanesulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / 0 °C

2: 61 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 75 percent / SnCl₂; aq. HCl / methanol / -10 - 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In methanol; dichloromethane;
DOI:10.1021/jm0508641