Technology Process of Benzoic acid (1R,4S,5R,6R)-4,5,6-tris-benzyloxymethoxy-cyclohex-2-enyl ester
There total 8 articles about Benzoic acid (1R,4S,5R,6R)-4,5,6-tris-benzyloxymethoxy-cyclohex-2-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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340013-50-5
Benzoic acid (1R,4S,4aR,5R,6R,7R,8S,8aS)-6,7,8-tris-benzyloxymethoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-methano-naphthalen-5-yl ester
- Guidance literature:
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With
sodium hydrogencarbonate;
In
diphenylether;
Heating;
DOI:10.1021/ol015733i
- Guidance literature:
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Multi-step reaction with 2 steps
1: Huenig base; TBAI / 1,2-dichloro-ethane
2: 92 percent / NaHCO3 / diphenyl ether / Heating
With
tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine;
In
diphenylether; 1,2-dichloro-ethane;
DOI:10.1021/ol015733i
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: HCl / methanol; tetrahydrofuran
2.1: pyridine
3.1: m-CPBA / pyridine
4.1: BF3*OEt2 / toluene
4.2: 76 percent / p-TsOH / CH2Cl2 / 72 h / 20 °C
5.1: 89 percent / Huenig base; TBAI / 1,2-dichloro-ethane
6.1: Zn; AcOH / methanol
7.1: Huenig base; TBAI / 1,2-dichloro-ethane
8.1: 92 percent / NaHCO3 / diphenyl ether / Heating
With
hydrogenchloride; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
In
tetrahydrofuran; pyridine; methanol; diphenylether; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ol015733i
