N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Base Information

Chemical Name:N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine
CAS No.:1436405-35-4
Molecular Formula:C₂₇H₂₅ClN₄O₅S
Molecular Weight:553.038
Hs Code.:

Synonyms:N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Suppliers and Price of N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

There total 11 articles about N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 845658-68-6
N-((5-bromofuran-2-yl)methyl)-2-(methylsulfonyl)ethanamine

: 1436405-34-3
4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-5-ethynyl-6-methylpyrimidine

: 1436405-35-4
N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 45 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1436405-35-4
N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 2 h / 20 °C

1.2: 4 h / 20 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 45 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 56-04-2
6-methyl-2-thiouracil

: 1436405-35-4
N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dihydrogen peroxide / water / 2 h / 70 - 90 °C

2.1: sodium hydroxide; iodine / water / 3 h / Reflux

3.1: trichlorophosphate / diethylene glycol dimethyl ether / 2 h / 90 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 60 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

5.2: 0.5 h / 0 °C

6.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 45 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dihydrogen peroxide; iodine; potassium carbonate; triethylamine; potassium iodide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.053