3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl

Base Information

• Chemical Name: 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl
• CAS No.: 129001-71-4
• Molecular Formula: C₆₆H₇₆N₂O₁₁
• Molecular Weight: 1073.34
• Mol file: 129001-71-4.mol

Synonyms:3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl

Chemical Property of 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl

There total 16 articles about 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(benzyloxy)-3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl (129001-70-3) → 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl (129001-71-4)

Guidance literature:

With trifluoroacetic acid; at 55 ℃; for 6h;

DOI:10.1021/ja00173a062

Reference yield:

3,5-bis(2-propenyl)-4-hydroxy-2',6'-dinitrobiphenyl (129001-65-6) → 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl (129001-71-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 18 h

2: 1.) 9-BBN, 2.) 3 M NaOH, 30percent H₂O₂ / 1.) THF, 65 deg C, 2.5 h, 2.) THF, below 28 deg C, 30 min

3: 88 percent / PPh₃, collidine, CBr₄ / CH₂Cl₂ / 2 h / -5 - -3 °C

4: 84 percent / Fe, NH₄Cl / H₂O; ethanol / 1.5 h / 65 - 70 °C

5: 60 percent / pyridine / tetrahydrofuran / 1.5 h / -60 - 10 °C

6: 70 percent / NaH, HMPA / tetrahydrofuran / 108 h / 35 °C

7: 70 percent / CF₃COOH / 5 h / 50 °C

With pyridine; 2,3,5-trimethyl-pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; carbon tetrabromide; dihydrogen peroxide; iron; sodium hydride; potassium carbonate; ammonium chloride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00021a042

Reference yield:

4-(benzyloxy)-3,5-bis(3-bromopropyl)-2',6'-diaminobiphenyl (129001-67-8) → 3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-4-hydroxy-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl (129001-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / pyridine / tetrahydrofuran / 1.5 h / -60 - 10 °C

2: 70 percent / NaH, HMPA / tetrahydrofuran / 108 h / 35 °C

3: 70 percent / CF₃COOH / 5 h / 50 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/ja00021a042

upstream raw materials:

4-(benzyloxy)-3,5-bis<3-(2-formyl-3,5-dimethylphenoxy)propyl>-2',6'-bis<6-(2-formyl-3,5-dimethylphenoxy)hexanamido>biphenyl

6-bromohexanoyl chloride

para-iodoanisole

4-methoxy-2',6'-dinitrobiphenyl