N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine

Base Information

• Chemical Name: N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine
• CAS No.: 864847-17-6
• Molecular Formula: C₃₄H₅₇FN₄O₅Si₃
• Molecular Weight: 705.105
• Mol file: 864847-17-6.mol

Synonyms:N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine

Chemical Property of N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine

There total 1 articles about N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluorophenylboronic acid (768-35-4) + 2',3',5'-tris-O-(tert-butyldimethylsilyl)-2'-deoxyinosine (110526-62-0) → N1-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine (864847-17-6)

Guidance literature:

With pyridine; pyridine N-oxide; oxygen; 4 A molecular sieve; copper diacetate; In dichloromethane; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1016/j.tetlet.2005.06.083

Reference yield: 86.0%

N1-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine (864847-17-6) → N1-(3-fluorophenyl)-inosine (1028803-39-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -10 ℃; for 1.5h;

Reference yield: 64.0%

N1-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine (864847-17-6) → 5-amino-4-N-3-fluorophenylcarboxamide-1-β-D-ribofuranosyl-1H-imidazole (1028803-41-9)

Guidance literature:

N₁-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine; With sodium hydroxide; In ethanol; water; for 4h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=~ 7;

upstream raw materials:

3-fluorophenylboronic acid

2',3',5'-tris-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Downstream raw materials:

N₁-(3-fluorophenyl)-inosine

5-amino-4-N-3-fluorophenylcarboxamide-1-β-D-ribofuranosyl-1H-imidazole