6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one

Base Information

Chemical Name:6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one
CAS No.:911064-54-5
Molecular Formula:C₁₁H₆FN₃OS₂
Molecular Weight:279.319
Hs Code.:

Synonyms:6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one

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Chemical Property of 6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one

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Technology Process of 6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one

There total 2 articles about 6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 18903-18-9
5-amino-thiazole-4-carboxylic acid ethyl ester

: 1544-68-9
4-fluorophenyl isothiocyanate

: 911064-54-5
6-(4-fluorophenyl)-5-thioxo-5,6-dihydro[1,3]thiazolo[5,4-d]pyrimidin-7(4H)-one

Guidance literature:: 5-amino-thiazole-4-carboxylic acid ethyl ester; 4-fluorophenyl isothiocyanate; dmap; In acetonitrile; for 24h; Heating / reflux;

With sodium hydroxide; water; at 80 ℃; for 0.5h;

With hydrogenchloride;

Reference yield:

: 18903-18-9
5-amino-thiazole-4-carboxylic acid ethyl ester

: 1544-68-9
4-fluorophenyl isothiocyanate

: 911064-54-5
6-(4-fluorophenyl)-5-mercapto[1,3]thiazolo[5,4]pyrimidin-7(6H)-one

Guidance literature:: 5-amino-thiazole-4-carboxylic acid ethyl ester; 4-fluorophenyl isothiocyanate; In pyridine; at 45 ℃; for 15h;

With sodium hydroxide; In water; at 90 ℃; for 15h;

Reference yield:

: 911064-54-5
6-(4-fluorophenyl)-5-mercapto[1,3]thiazolo[5,4]pyrimidin-7(6H)-one

: 1009032-28-3
6-(4-fluorophenyl)-5-mercapto[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one hydrochloride

Guidance literature:: 6-(4-fluorophenyl)-5-mercapto[1,3]thiazolo[5,4]pyrimidin-7(6H)-one; With hydrogenchloride; In water; at 90 ℃; for 15h;

pH=3;