methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

Base Information

Chemical Name:methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate
CAS No.:1247015-92-4
Molecular Formula:C₁₂H₁₂FN₅O₂
Molecular Weight:277.258
Hs Code.:

Synonyms:methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

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Technology Process of methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

There total 1 articles about methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 506-68-3
bromocyane

: C₁₁H₁₂FNO₂

: 1247015-92-4
methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

Guidance literature:: bromocyane; With sodium azide; In acetonitrile; at 0 - 10 ℃; for 4h;

C₁₁H₁₂FNO₂; In water; acetonitrile; at 0 - 10 ℃;
DOI:10.1002/ejoc.201000586

Reference yield: 91.0%

: 1247015-92-4
methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate

: 1247016-01-8
2-azido-5-(2-fluorobenzyl)pyrimidin-4(3H)-one

Guidance literature:: methyl (E)-2-[(5-amino-1H-1,2,3,4-tetrazol-1-yl)methyl]-3-(2-fluorophenyl)prop-2-enoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

With hydrogenchloride; In water; pH=2;
DOI:10.1002/ejoc.201000586