{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

Base Information

Chemical Name:{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid
CAS No.:1313215-82-5
Molecular Formula:C₂₄H₂₈N₄O₄S
Molecular Weight:468.577
Hs Code.:

Synonyms:{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

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Chemical Property of {6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

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Technology Process of {6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

There total 4 articles about {6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1313217-08-1
tert-butyl (tert-butoxycarbonyl {6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

: 1313215-82-5
{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

Guidance literature:: tert-butyl (tert-butoxycarbonyl {6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

With water; sodium hydroxide; pH=4.5;

Reference yield:

: 58313-23-8
3-iodobenzoic acid methyl ester

: 1313215-82-5
{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16.25 h / 20 °C

3.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

4.2: pH 4.5

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; tributylphosphine; diamide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1313217-89-8
ethyl 3-butylbenzoate

: 1313215-82-5
{6-[(3-butylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16.25 h / 20 °C

2.1: tributylphosphine; diamide / tetrahydrofuran / 16 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 20 °C

3.2: pH 4.5

With hydrogenchloride; lithium aluminium tetrahydride; tributylphosphine; diamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;