HALOFUGINONE LACTATE

Base Information

• Chemical Name: HALOFUGINONE LACTATE
• CAS No.: 82186-71-8
• Molecular Formula: C₃H₆O₃*C₁₆H₁₇BrClN₃O₃
• Molecular Weight: 504.765
• Mol file: 82186-71-8.mol

Synonyms:halofuginonlactat;

Chemical Property of HALOFUGINONE LACTATE

Chemical Property:

• Vapor Pressure: 4.84E-15mmHg at 25°C
• Boiling Point: 595.8°Cat760mmHg
• Flash Point: 314.1°C
• PSA: 141.75000
• Density: g/cm³
• LogP: 1.66510
• Storage Temp.: 0-6°C

Purity/Quality:

HPLC 98% ^*data from raw suppliers

HalofuginoneLactate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Halofuginone Lactate is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.
• Uses: Halofuginone is a halogenated derivative of Febrifugine (F228500). Halofuginone is used as an antiprotozoal. It is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.Integration of halofuginone lactate treatment and disinfection with p-chloro-m-cresol to control natural cryptosporidiosis in calves

Technology Process of HALOFUGINONE LACTATE

There total 10 articles about HALOFUGINONE LACTATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone (55837-20-2) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) → (rac)-halofuginone lactate (82186-71-8)

Guidance literature:

In water; at 20 ℃;

Reference yield:

C7H12ClNO2 → (rac)-halofuginone lactate (82186-71-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium carbonate; tetra-(n-butyl)ammonium iodide / toluene / 0.33 h / 20 °C / Large scale

1.2: 75 - 80 °C / Large scale

1.3: 20 - 25 °C / Large scale

2.1: sodium t-butanolate / tetrahydrofuran / 5 - 20 °C / Inert atmosphere; Large scale

3.1: lithium chloride; water / N,N-dimethyl-formamide / 120 °C / Large scale

4.1: ethanol; sodium tetrahydroborate / 5 - 20 °C / Large scale

5.1: hydrogenchloride / water; ethanol / Reflux; Large scale

6.1: sodium carbonate / water; 1,4-dioxane / 5 - 20 °C / Large scale

7.1: N-Bromosuccinimide; water / acetonitrile / 0 - 5 °C / Large scale

8.1: lithium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Large scale

8.2: 0 - 5 °C / Large scale

8.3: 0 - 5 °C / Large scale

9.1: ethanol / Reflux; Large scale

10.1: water / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; ethanol; water; tetra-(n-butyl)ammonium iodide; sodium carbonate; lithium chloride; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

C21H28ClNO6 → (rac)-halofuginone lactate (82186-71-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium t-butanolate / tetrahydrofuran / 5 - 20 °C / Inert atmosphere; Large scale

2.1: lithium chloride; water / N,N-dimethyl-formamide / 120 °C / Large scale

3.1: ethanol; sodium tetrahydroborate / 5 - 20 °C / Large scale

4.1: hydrogenchloride / water; ethanol / Reflux; Large scale

5.1: sodium carbonate / water; 1,4-dioxane / 5 - 20 °C / Large scale

6.1: N-Bromosuccinimide; water / acetonitrile / 0 - 5 °C / Large scale

7.1: lithium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Large scale

7.2: 0 - 5 °C / Large scale

7.3: 0 - 5 °C / Large scale

8.1: ethanol / Reflux; Large scale

9.1: water / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; ethanol; water; sodium carbonate; lithium chloride; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone

LACTIC ACID

Refernces