5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Base Information

Chemical Name:5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid
CAS No.:259150-12-4
Molecular Formula:C₁₇H₁₃N₃O₅
Molecular Weight:339.307
Hs Code.:

Synonyms:DJOISNDFTVMSQG-UHFFFAOYSA-N;5-(benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Suppliers and Price of 5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:339.08552052
Heavy Atom Count:25
Complexity:532

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)N=C(C2=CN=C3C(=C2)C=C(O3)C(=O)O)N

Technology Process of 5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

There total 7 articles about 5-(Benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: ethyl 5-amidinofuro[2,3-b]pyridine-2-carboxylate hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 259150-12-4
5-(benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 6563-64-0
ethyl 5-nitrofuro[2,3-b]pyridine-2-carboxylate

: 259150-12-4
5-(benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

2.1: 12N aq. HCl; NaNO₂ / tetrahydrofuran / 0.33 h / 2 - 3 °C

2.2: 20 percent / KCN / 3.5 h / 3 - 50 °C

3.1: aq. LiOH / tetrahydrofuran / 1 h / 20 °C

4.1: HCl

5.1: NH₃ / ethanol

6.1: aq. NaOH / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; sodium hydroxide; ammonia; hydrogen; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1.1: Reduction / 2.1: Diazotization / 2.2: Sandmeyer reaction / 3.1: Hydrolysis / 4.1: Pinner reaction / 5.1: aminolysis / 6.1: Acylation;
DOI:10.1248/cpb.47.1694

Reference yield:

: 174775-52-1
5-cyanofuro[2,3-b]pyridine-2-carboxylic acid

: 259150-12-4
5-(benzyloxycarbonylamidino)furo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: HCl

2: NH₃ / ethanol

3: aq. NaOH / tetrahydrofuran

With hydrogenchloride; sodium hydroxide; ammonia; In tetrahydrofuran; ethanol; 1: Pinner reaction / 2: aminolysis / 3: Acylation;
DOI:10.1248/cpb.47.1694