3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester

Base Information

• Chemical Name: 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester
• CAS No.: 1616664-92-6
• Molecular Formula: C₁₄H₁₉FN₂O₂
• Molecular Weight: 266.315
• Mol file: 1616664-92-6.mol

Synonyms:3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester

Chemical Property of 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester

There total 4 articles about 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-methyl-piperazine (109-01-3) + methyl 4-(bromomethyl)-3-fluorobenzoate (128577-47-9) → 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester (1616664-92-6)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux; Inert atmosphere;

Reference yield: 49.0%

→ 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester (1616664-92-6)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux; Inert atmosphere;

Reference yield:

3-fluoro-4-methyl-benzoic acid (350-28-7) → 3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid methyl ester (1616664-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: N-Bromosuccinimide; Perbenzoic acid / tetrachloromethane; water / 6 h / Reflux

3: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

With N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; potassium carbonate; In tetrachloromethane; water; acetonitrile;

upstream raw materials:

1-methyl-piperazine

methyl 4-(bromomethyl)-3-fluorobenzoate

3-fluoro-4-methyl-benzoic acid

methyl 3-fluoro-4-methylbenzoate

Downstream raw materials:

3-fluoro-4-(4-methylpiperazin-1-ylmethyl)-benzoic acid