(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one
CAS No.:885685-87-0
Molecular Formula:C₂₉H₃₄BrNO₃Si
Molecular Weight:552.583
Hs Code.:

Synonyms:(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

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Chemical Property of (3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

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Technology Process of (3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

There total 5 articles about (3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885685-94-9
(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 885685-87-0
(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂ / Pd/C / ethyl acetate

2: TMSOTf; Et₃N; NBS / CH₂Cl₂ / 0 °C

With N-Bromosuccinimide; trimethylsilyl trifluoromethanesulfonate; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2006.01.047

Reference yield:

: 885685-93-8
5-(tert-butyl-diphenyl-silanyloxymethyl)-3-[hydroxy-(2-methoxy-phenyl)-methyl]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 885685-87-0
(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Ph₃P; I₂; imidazole / CH₂Cl₂ / 0 - 20 °C

2: 93 percent / H₂ / Pd/C / ethyl acetate

3: TMSOTf; Et₃N; NBS / CH₂Cl₂ / 0 °C

With 1H-imidazole; N-Bromosuccinimide; trimethylsilyl trifluoromethanesulfonate; hydrogen; iodine; triethylamine; triphenylphosphine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2006.01.047

Reference yield:

: 138629-30-8,138871-56-4
(S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate

: 885685-87-0
(3R,5S)-3-Bromo-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-benzyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiHMDS / tetrahydrofuran / -78 °C

1.2: 99 percent / BF₃*OEt₂ / tetrahydrofuran

2.1: 92 percent / Ph₃P; I₂; imidazole / CH₂Cl₂ / 0 - 20 °C

3.1: 93 percent / H₂ / Pd/C / ethyl acetate

4.1: TMSOTf; Et₃N; NBS / CH₂Cl₂ / 0 °C

With 1H-imidazole; N-Bromosuccinimide; trimethylsilyl trifluoromethanesulfonate; hydrogen; iodine; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2006.01.047