N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

Base Information

• Chemical Name: N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide
• CAS No.: 1333494-90-8
• Molecular Formula: C₄₅H₆₀N₆O₈
• Molecular Weight: 813.007
• Mol file: 1333494-90-8.mol

Synonyms:N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

Chemical Property of N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide

There total 14 articles about N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C50H68N6O10 → N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide (1333494-90-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmc.2011.07.002

Reference yield:

C26H34N2O4 → N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide (1333494-90-8)

Guidance literature:

Multi-step reaction with 9 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

7: diethylamine / N,N-dimethyl-formamide / 20 °C

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

9: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.07.002

Reference yield:

C21H26N2O2 → N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide (1333494-90-8)

Guidance literature:

Multi-step reaction with 8 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

6: diethylamine / N,N-dimethyl-formamide / 20 °C

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

8: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.07.002

upstream raw materials:

iodobenzene

1-phenylcyclopentanol

1-(1-azidocyclopentyl)benzene

1-phenylcyclopentylamine