5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole

Base Information

• Chemical Name: 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole
• CAS No.: 1374351-14-0
• Molecular Formula: C₂₈H₂₇FN₆O
• Molecular Weight: 482.56
• Mol file: 1374351-14-0.mol

Synonyms:5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole

Chemical Property of 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole

There total 11 articles about 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H20N6 (1374353-22-6) + 2-fluoro-6-methoxybenzaldehyde (146137-74-8) → 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole (1374351-14-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 3h;

Reference yield:

4-pyridylboronic acid (1692-15-5) → 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole (1374351-14-0)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

2: hydrogen / palladium 10% on activated carbon / toluene; methanol

3: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / acetonitrile; water / 4 h / 10 - 20 °C

4: potassium carbonate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 96 h / 100 °C

5: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C

6: sodium tris(acetoxy)borohydride / tetrahydrofuran / 3 h

With triethylsilane; potassium phosphate; copper(l) iodide; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; toluene-4-sulfonic acid; trans-N,N'-dimethylcyclohexane-1,2-diamine; trifluoroacetic acid; potassium iodide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

3-bromo-5-nitro-1-trityl-1H-indazole (942189-39-1) → 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole (1374351-14-0)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

2: hydrogen / palladium 10% on activated carbon / toluene; methanol

3: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / acetonitrile; water / 4 h / 10 - 20 °C

4: potassium carbonate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 96 h / 100 °C

5: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C

6: sodium tris(acetoxy)borohydride / tetrahydrofuran / 3 h

With triethylsilane; potassium phosphate; copper(l) iodide; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; toluene-4-sulfonic acid; trans-N,N'-dimethylcyclohexane-1,2-diamine; trifluoroacetic acid; potassium iodide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

upstream raw materials:

N-(tert-butyloxycarbonyl)nipecotic acid

4-pyridylboronic acid

C₂₀H₂₀N₆

2-fluoro-6-methoxybenzaldehyde