5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

Base Information

Chemical Name:5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol
CAS No.:656240-40-3
Molecular Formula:C₃₀H₄₀O₄Si
Molecular Weight:492.731
Hs Code.:

5-(<i>tert</i>-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

Synonyms:5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

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Chemical Property of 5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

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Technology Process of 5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

There total 10 articles about 5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 656240-52-7
acetic acid 5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentyl ester

: 656240-40-3
5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 0.166667h;
DOI:10.1055/s-2003-42097

Reference yield:

: 656240-50-5
4-iodo-2-methoxymethoxy-1-methyl-benzene

: 656240-40-3
5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 97 percent / Et₃N; CuI / (PPh₃)2PdCl₂ / benzene / 1 h / 25 °C

2.1: 91 percent / LiAlH₄ / tetrahydrofuran / 1 h / 25 °C

3.1: 100 percent / Hg(OCOCF₃)2 / 19 h / Heating

4.1: 87 percent / i-Bu₃Al / CH₂Cl₂ / 0.5 h / 25 °C

5.1: BH₃*SMe₂ / tetrahydrofuran / 25 °C

5.2: 91 percent / aq. NaOH; H₂O₂ / 2 h / 25 °C

6.1: 53 percent / lipase AK / benzene / 17 h / 25 °C

7.1: 100 percent / imidazole; 4-DMAP / CH₂Cl₂ / 0.33 h / 25 °C

8.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / 25 °C

With 1H-imidazole; dmap; copper(l) iodide; lithium aluminium tetrahydride; lipase AK; dimethylsulfide borane complex; triisobutylaluminum; mercury(II) trifluoroacetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; benzene; 1.1: Sonogashira coupling / 4.1: Claisen rearrangement;
DOI:10.1055/s-2003-42097

Reference yield:

: (E)-3-(3-Methoxymethoxy-4-methyl-phenyl)-prop-2-en-1-ol

: 656240-40-3
5-(tert-butyl-diphenyl-silanyloxy)-3-(3-methoxymethoxy-4-methyl-phenyl)-pentan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / Hg(OCOCF₃)2 / 19 h / Heating

2.1: 87 percent / i-Bu₃Al / CH₂Cl₂ / 0.5 h / 25 °C

3.1: BH₃*SMe₂ / tetrahydrofuran / 25 °C

3.2: 91 percent / aq. NaOH; H₂O₂ / 2 h / 25 °C

4.1: 53 percent / lipase AK / benzene / 17 h / 25 °C

5.1: 100 percent / imidazole; 4-DMAP / CH₂Cl₂ / 0.33 h / 25 °C

6.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / 25 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; lipase AK; dimethylsulfide borane complex; triisobutylaluminum; mercury(II) trifluoroacetate; In tetrahydrofuran; dichloromethane; benzene; 2.1: Claisen rearrangement;
DOI:10.1055/s-2003-42097