Technology Process of 5-{3-(4-fluorophenyl)-7-[1-(2-methylpropyl)-1H-1,2,3-triazol-4-yl]-4-oxo-3,4-dihydroquinazolin-2-yl}pentanoic acid
There total 7 articles about 5-{3-(4-fluorophenyl)-7-[1-(2-methylpropyl)-1H-1,2,3-triazol-4-yl]-4-oxo-3,4-dihydroquinazolin-2-yl}pentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Isobutyl bromide;
With
sodium azide;
In
water; tert-butyl alcohol;
at 70 ℃;
for 48h;
methyl 5-(7-ethynyl-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate;
With
copper;
In
water; tert-butyl alcohol;
at 25 - 125 ℃;
for 48.3333h;
microwave irradiation;
With
sodium hydroxide;
In
tetrahydrofuran; water; tert-butyl alcohol;
at 45 ℃;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 0 - 40 °C
2.1: acetic anhydride / 5 h / 150 °C
3.1: acetic acid / 1 h / 100 °C
4.1: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.17 h / 60 °C / microwave irradiation; Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / -30 °C / Inert atmosphere
6.1: sodium azide / water; tert-butyl alcohol / 48 h / 70 °C
6.2: 48.33 h / 25 - 125 °C / microwave irradiation
6.3: 0.33 h / 45 °C
With
copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 0 - 40 °C
2.1: acetic anhydride / 5 h / 150 °C
3.1: acetic acid / 1 h / 100 °C
4.1: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.17 h / 60 °C / microwave irradiation; Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / -30 °C / Inert atmosphere
6.1: sodium azide / water; tert-butyl alcohol / 48 h / 70 °C
6.2: 48.33 h / 25 - 125 °C / microwave irradiation
6.3: 0.33 h / 45 °C
With
copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
