1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine

Base Information

• Chemical Name: 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine
• CAS No.: 1454855-03-8
• Molecular Formula: C₂₃H₂₈FN₅
• Molecular Weight: 393.507
• Mol file: 1454855-03-8.mol

Synonyms:1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine

Chemical Property of 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine

There total 5 articles about 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-ethynyl-3-fluoro-benzene (2561-17-3) + 1-(3-azidopropyl)-4-(3,4-dimethylphenyl)piperazine → 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine (1454855-03-8)

Guidance literature:

With copper nanoparticles on activated carbon; In 1,4-dioxane; at 60 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

C11H10FN3O (1454858-04-8) + 1-(3,4-dimethylphenyl)piperazine (1014-05-7) → 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine (1454855-03-8)

Guidance literature:

C₁₁H₁₀FN₃O; 1-(3,4-dimethylphenyl)piperazine; In dichloromethane; at 20 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Molecular sieve;

With sodium tris(acetoxy)borohydride; for 12h;

DOI:10.5012/bkcs.2013.34.11.3467

Reference yield:

C11H12FN3O (1454857-92-1) → 1-(3,4-dimethylphenyl)-4-(3-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazine (1454855-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethylsulfone / dichloromethane / 0.5 h / -78 °C

1.2: 1.08 h / -78 - 20 °C

2.1: dichloromethane / 0.17 h / 20 °C

2.2: 0.5 h / Molecular sieve

2.3: 12 h

With oxalyl dichloride; dimethylsulfone; In dichloromethane;

DOI:10.5012/bkcs.2013.34.11.3467

upstream raw materials:

C₁₁H₁₂FN₃O

C₁₁H₁₀FN₃O

1-(3,4-dimethylphenyl)piperazine

1-(3-chloropropyl)-4-(3,4-dimethylphenyl)piperazine