Technology Process of C13H18O2
There total 1 articles about C13H18O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl-4-bromoanisole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.75h;
Inert atmosphere;
N-methoxy-N,3-dimethylbutanamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
Inert atmosphere;
DOI:10.1021/ol301332f
- Guidance literature:
-
C13H18O2;
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 1h;
Inert atmosphere;
Allyl chloroformate;
In
tetrahydrofuran; toluene;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol301332f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tris-(dibenzylideneacetone)dipalladium(0); 2,4,6-tri-tert-butylphenoxol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol / tetrahydrofuran / 7 h / 0 °C / Inert atmosphere
3.1: oxygen; copper diacetate; palladium dichloride / N,N-dimethyl acetamide; water / 760.05 Torr / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); 2,4,6-tri-tert-butylphenoxol; oxygen; copper diacetate; potassium hexamethylsilazane; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; palladium dichloride;
In
tetrahydrofuran; N,N-dimethyl acetamide; water; toluene;
3.1: Wacker oxidation;
DOI:10.1021/ol301332f
