S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

Base Information

• Chemical Name: S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil
• CAS No.: 119835-96-0
• Molecular Formula: C₃₀H₂₇N₃O₇
• Molecular Weight: 541.56

Synonyms:S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

Chemical Property of S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

Chemical Property:

Purity/Quality:

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Technology Process of S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

There total 12 articles about S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-95-9) → S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil (119835-96-0)

Guidance literature:

With hydrogenchloride; In methanol; at 40 ℃; for 8h;

DOI:10.1002/jhet.5570250561

Reference yield:

potassium phtalimide (1074-82-4) → S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil (119835-96-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / dimethylformamide / 0.5 h / 120 °C

2: HCl (g) / CH₂Cl₂ / 3 h / 0 °C

3: 75 percent / K₂CO₃ (s) / CH₂Cl₂ / 48 h / Ambient temperature

4: H₂, 6 N HCl / 10percent Pd/C / methanol; CH₂Cl₂ / 0.5 h / 2280 Torr

5: 1.60 g / NaI, K₂CO₃ / acetone / 3 h / Heating

6: 84 percent / 6 N HCl / methanol / 8 h / 40 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1002/jhet.5570250561

Reference yield:

S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-93-7) → S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil (119835-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, 6 N HCl / 10percent Pd/C / methanol; CH₂Cl₂ / 0.5 h / 2280 Torr

2: 1.60 g / NaI, K₂CO₃ / acetone / 3 h / Heating

3: 84 percent / 6 N HCl / methanol / 8 h / 40 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; acetone;

DOI:10.1002/jhet.5570250561

upstream raw materials:

S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

potassium phtalimide

S-(-)-3-phthalimido-1,2-propanediol

1H-isoindole-1,3(2H)-dione, 2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]

Downstream raw materials:

S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-aminomethyl-2'-hydroxyethoxy)methyl>uracil

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