(+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Base Information

• Chemical Name: (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS No.: 889885-89-6
• Molecular Formula: C₅₀H₄₉N₆O₆P
• Molecular Weight: 860.949

Synonyms:(+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property of (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Useful:

Technology Process of (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

There total 7 articles about (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-(4-monomethoxytrityl)amino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-77-2) → (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-89-6)

Guidance literature:

With trimethylsilyl iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1080/15257770500265315

Reference yield:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-74-9) → (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-89-6)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 20 h / 20 °C

2: 458 mg / NaN₃ / dimethylformamide / 4 h / 100 °C

3: 85 percent / PPh₃; H₂O / tetrahydrofuran / 14 h / 20 °C

4: 87 percent / pyridine / 16 h / 70 °C

5: 45 percent / Et₃N; trimethylsilyl iodide / dimethylformamide / 16 h / 20 °C

With pyridine; sodium azide; trimethylsilyl iodide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/15257770500265315

Reference yield:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-azido)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-75-0) → (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / PPh₃; H₂O / tetrahydrofuran / 14 h / 20 °C

2: 87 percent / pyridine / 16 h / 70 °C

3: 45 percent / Et₃N; trimethylsilyl iodide / dimethylformamide / 16 h / 20 °C

With pyridine; trimethylsilyl iodide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/15257770500265315

upstream raw materials:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-(4-monomethoxytrityl)amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-azido)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Downstream raw materials:

(+/-)-9-[1-[(di-isopropyloxycarbonyloxymethylphosphonomethoxy)methyl](3-(4-monomethyxytrityl)amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

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