5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

Base Information

Chemical Name:5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol
CAS No.:193278-23-8
Molecular Formula:C₂₂H₃₀N₈O₈S
Molecular Weight:566.595
Hs Code.:

Synonyms:5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

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Technology Process of 5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

There total 5 articles about 5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 180250-77-5
Ng-nitroargininal ethyl cyclol hydrochloride

: 179524-01-7
5-Benzylsulfonylamino-1-methyl-3-uracilylacetic Acid

: 193278-23-8
5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: 28495-88-7
1-methyl-5-nitrouracil

: 193278-23-8
5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / NaH / dimethylformamide

2: 81 percent / H₂ / Pd/C / ethanol

3: 94 percent / NMM

4: 88 percent / CF₃COOH / CH₂Cl₂

5: 82 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: (5-Amino-3-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-acetic acid tert-butyl ester

: 193278-23-8
5-benzylsulfonylamino-1-methyl-3-uracilylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NMM

2: 88 percent / CF₃COOH / CH₂Cl₂

3: 82 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8