1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

Base Information

Chemical Name:1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one
CAS No.:1404285-94-4
Molecular Formula:C₂₄H₂₃NO₂S
Molecular Weight:389.518
Hs Code.:

Synonyms:1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

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Chemical Property of 1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

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Technology Process of 1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

There total 4 articles about 1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 591-50-4
iodobenzene

: 1404285-92-2
C₁₈H₁₉NO₂S

: 1404285-94-4
1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

Guidance literature:: With [2,2]bipyridinyl; silver carbonate; palladium dichloride; In m-xylene; at 150 ℃; for 12h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.038

Reference yield:

: 1351469-61-8
1-benzyl-4-[3-(2,2-dimethoxyethyl)thiophen-2-yl]piperidin-4-ol

: 1404285-94-4
1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

1.2: pH 8

2.1: pyridinium chlorochromate / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: palladium dichloride; silver carbonate; [2,2]bipyridinyl / m-xylene / 12 h / 150 °C / Inert atmosphere

With hydrogenchloride; [2,2]bipyridinyl; silver carbonate; pyridinium chlorochromate; palladium dichloride; In tetrahydrofuran; dichloromethane; water; m-xylene;
DOI:10.1016/j.bmc.2013.01.038

Reference yield:

: 1351469-60-7
2-(4-bromothiophen-3-yl)acetaldehyde dimethyl acetal

: 1404285-94-4
1-benzyl-2'-phenylspiro(piperidine-4,7'-thieno[2,3-c]pyran)-5'-(4'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

1.3: 20 °C

2.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

2.2: pH 8

3.1: pyridinium chlorochromate / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: palladium dichloride; silver carbonate; [2,2]bipyridinyl / m-xylene / 12 h / 150 °C / Inert atmosphere

With hydrogenchloride; [2,2]bipyridinyl; n-butyllithium; silver carbonate; pyridinium chlorochromate; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane; water; m-xylene;
DOI:10.1016/j.bmc.2013.01.038