N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

Base Information

Chemical Name:N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride
CAS No.:1372180-66-9
Molecular Formula:C₁₅H₂₀Cl₂N₂O₂*ClH
Molecular Weight:367.703
Hs Code.:

Synonyms:N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

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Chemical Property of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

Chemical Property:

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Technology Process of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

There total 15 articles about N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-57-9
tert-butyl (6R,7R)-6-{[acetyl(methyl)amino]methyl}-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372180-66-9
N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃; for 1h;

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1372180-66-9
N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

Guidance literature:: Multi-step reaction with 15 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 48 h / 10 - 35 °C

2.1: triethylamine / methanol / 72 h / 10 - 35 °C

3.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.2: 0.5 h

4.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

6.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

7.2: 2 h / -78 - 35 °C

8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

8.2: 18 h / 80 °C

8.3: 2 h / 35 °C / Cooling with ice

9.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

10.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

11.1: sodium azide / N,N-dimethyl-formamide / 70 °C

12.1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

13.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

14.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice

14.2: 10 - 35 °C / Cooling with ice

15.1: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; triethylamine; triphenylphosphine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 12.1: Staudinger Reaction;

Reference yield:

: 1372186-95-2
tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372180-66-9
N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)-N-methylacetamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

2.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

3.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice

3.2: 10 - 35 °C / Cooling with ice

4.1: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 1.1: Staudinger Reaction;