4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

Base Information

Chemical Name:4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone
CAS No.:1192261-29-2
Molecular Formula:C₂₄H₁₆F₃N₅O₃
Molecular Weight:479.418
Hs Code.:

Synonyms:4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

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Chemical Property of 4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

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Technology Process of 4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

There total 5 articles about 4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1192261-61-2
4-(5-amino-quinolinyl-8-oxy)-pyridine-5,6-imidazolone

: 2003-14-7
(3-trifluoromethyl-phenyl)-acetyl chloride

: 1192261-29-2
4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

Guidance literature:: With triethylamine; In 1,4-dioxane; at 80 ℃; for 20h;

Reference yield:

: 6980-08-1
4-chloro-3-nitro-2-pyridinamine

: 1192261-29-2
4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h

1.2: 5 h / 85 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 18 h / 20 °C

3.1: pyridine / tetrahydrofuran / Cooling with ice; Reflux

4.1: trifluoroacetic acid / 2.5 h / 20 °C

4.2: pH 7.5 - 8

5.1: triethylamine / 1,4-dioxane / 20 h / 80 °C

With pyridine; potassium tert-butylate; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1192261-73-6
tert-butyl (8-hydroxyquinolin-5-yl)carbamate

: 1192261-29-2
4-[(8-oxy-quinolinyl-5-amino)carbonyl-methyl-(3-trifluoromethyl-phenyl)]-pyridin-5,6-imidazolone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h

1.2: 5 h / 85 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 18 h / 20 °C

3.1: pyridine / tetrahydrofuran / Cooling with ice; Reflux

4.1: trifluoroacetic acid / 2.5 h / 20 °C

4.2: pH 7.5 - 8

5.1: triethylamine / 1,4-dioxane / 20 h / 80 °C

With pyridine; potassium tert-butylate; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide;