(S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate
CAS No.:1040749-35-6
Molecular Formula:C₂₀H₁₉F₂NO₄
Molecular Weight:375.372
Hs Code.:

Synonyms:(S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

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Technology Process of (S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

There total 2 articles about (S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 923568-90-5
N-t-butoxycarbonyl-3-(4-fluorophenyl)-5-methoxy-2-oxindole

: 1040749-35-6
(S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

Guidance literature:: N-t-butoxycarbonyl-3-(4-fluorophenyl)-5-methoxy-2-oxindole; With nickel(II) perchlorate hexahydrate; (1Z,3Z)-1,3-bis{[(S)-4-phenyl-4,5-dihydrooxazol-2-yl]methylene}isoindoline; In diethyl ether; at 20 ℃; for 0.5h; Inert atmosphere; Molecular sieve;

With N-fluorobis(benzenesulfon)imide; In diethyl ether; at 20 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/chem.201102375

Reference yield:

: 923568-90-5
N-t-butoxycarbonyl-3-(4-fluorophenyl)-5-methoxy-2-oxindole

: (R)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

: 1040749-35-6
(S)-tert-butyl 3-fluoro-3-(4-fluorophenyl)-5-methoxy-2-oxoindoline-1-carboxylate

Guidance literature:: With cesium hydroxide monohydrate; N-fluorobis(benzenesulfon)imide; hydroquinidine (anthraquinone-1,4-diyl) diether; In dichloromethane; acetonitrile; at -80 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.200800717