tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate
CAS No.:865536-40-9
Molecular Formula:C₁₉H₂₆N₄O₄
Molecular Weight:374.44
Hs Code.:

Synonyms:tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

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Chemical Property of tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

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Technology Process of tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

There total 1 articles about tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54965-59-2
2-chloro-4-methyl-6-nitroquinoline

: 865536-40-9
tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / 55 °C

2: triethylamine / dichloromethane / 12 h / 20 °C

With triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2017.07.080

Reference yield:

: 865536-40-9
tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

: N-[2-(2-dimethylamino-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂ / Pd/C / tetrahydrofuran / 12 h / 760 Torr

2: 98 percent / CH₂Cl₂ / 3 h

3: 70 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050103y

Reference yield:

: 865536-40-9
tert-butyl (2-dimethylaminoethyl)-(4-methyl-6-nitroquinolin-2-yl)carbamate

: 865536-53-4
tert-butyl (2-dimethylaminoethyl)-{4-methyl-6-[(E)-3-(4-trifluoromethoxyphenyl)acryloylamino]quinolin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / H₂ / Pd/C / tetrahydrofuran / 12 h / 760 Torr

2: 98 percent / CH₂Cl₂ / 3 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050103y