Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

Base Information

Chemical Name:Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe
CAS No.:820226-05-9
Molecular Formula:C₄₈H₈₀N₆O₁₂Si
Molecular Weight:961.282
Hs Code.:

Z-Val-Thr(TBS)-Val-Thr(ψ<sup>Me,Me</sup>pro)-Val-Thr(ψ<sup>Me,Me</sup>pro)-OMe

Synonyms:Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

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Chemical Property of Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

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Technology Process of Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

There total 9 articles about Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7352-28-5
N-(benzyloxycarbonyl)-L-valyl-L-threonine methyl ester

: 820226-05-9
Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / camphorsulfonic acid / CH₂Cl₂ / 5 h / 0 °C

2: 99 percent / aq. LiOH / methanol / 6 h / 20 °C

3: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂; dimethylformamide / 0 - 20 °C

4: 100 percent / TBAF / tetrahydrofuran / 0 - 20 °C

5: 82 percent / camphorsulfonic acid / CH₂Cl₂ / 5 h / 0 °C

6: 99 percent / H₂ / Pd/C / methanol / 5 h

7: 55 percent / DIPEA; PyBOP; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; lithium hydroxide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732

Reference yield:

: 108543-84-6
N-(benzyloxycarbonyl)-L-valyl-O-(tert-butyldimethylsilyl)-L-threonine methyl ester

: 820226-05-9
Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol / 5 h

2: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂; dimethylformamide / 0 - 20 °C

3: 100 percent / TBAF / tetrahydrofuran / 0 - 20 °C

4: 82 percent / camphorsulfonic acid / CH₂Cl₂ / 5 h / 0 °C

5: 99 percent / H₂ / Pd/C / methanol / 5 h

6: 55 percent / DIPEA; PyBOP; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732

Reference yield:

: 820225-80-7
Val-Thr(TBS)-OMe

: 820226-05-9
Z-Val-Thr(TBS)-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂; dimethylformamide / 0 - 20 °C

2: 100 percent / TBAF / tetrahydrofuran / 0 - 20 °C

3: 82 percent / camphorsulfonic acid / CH₂Cl₂ / 5 h / 0 °C

4: 99 percent / H₂ / Pd/C / methanol / 5 h

5: 55 percent / DIPEA; PyBOP; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732