2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

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Chemical Name:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine
CAS No.:1332875-29-2
Molecular Formula:C₂₀H₁₈ClF₃N₆
Molecular Weight:434.851
Hs Code.:

Synonyms:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

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Chemical Property of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

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Technology Process of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

There total 9 articles about 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

: 1332875-29-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

Guidance literature:: 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide; acetic acid; at 100 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 685513-51-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid

: 1332875-29-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

2.2: 2 h / 20 °C

3.1: 1,4-dioxane / 2 h / 65 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; toluene; water / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / 3 h / 65 °C

6.1: acetic acid / 100 °C

With oxalyl dichloride; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Suzuki Coupling;

Reference yield:

: 286837-90-9
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride

: 1332875-29-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

1.2: 2 h / 20 °C

2.1: 1,4-dioxane / 2 h / 65 °C

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; toluene; water / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / 3 h / 65 °C

5.1: acetic acid / 100 °C

With sodium hydride; potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 3.1: Suzuki Coupling;