3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

Base Information

Chemical Name:3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol
CAS No.:838857-23-1
Molecular Formula:C₁₅H₂₀FN₃O₂
Molecular Weight:293.341
Hs Code.:

Synonyms:3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

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Chemical Property of 3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

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Technology Process of 3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

There total 11 articles about 3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 838857-21-9
1-(1,1-dimethylethyl)-4-{5-fluoro-2-(methyloxy)-3-[(phenylmethyl)oxy]phenyl}-3-methyl-1H-pyrazol-5-amine

: 838857-23-1
3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; for 2h; under 2068.65 Torr;

Reference yield:

: 838857-05-9
6-fluoro-2,2-dimethyl-4H-1,3-benzodioxine-8-carbaldehyde

: 838857-23-1
3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,1-dichloroethane / 0.33 h / 70 °C

1.2: 0.33 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1.75 h / 20 °C

3.1: hydrogenchloride; water / ethanol / 0.33 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C

6.1: N,N-dimethyl-formamide / 2.33 h / 50 °C

7.1: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

8.1: ethanol / 16 h / 20 - 75 °C

9.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

With hydrogenchloride; thionyl chloride; water; hydrogen; sodium hydride; caesium carbonate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 838857-15-1
1-(chloromethyl)-5-fluoro-2-(methyloxy)-3-[(phenylmethyl)oxy]benzene

: 838857-23-1
3-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-5-fluoro-2-(methyloxy)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 2.33 h / 50 °C

2: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

3: ethanol / 16 h / 20 - 75 °C

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;