1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Base Information

Chemical Name:1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester
CAS No.:149046-40-2
Molecular Formula:C₂₃H₂₂N₂O₆
Molecular Weight:422.437
Hs Code.:

Synonyms:1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

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Chemical Property of 1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

There total 9 articles about 1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 149046-39-9
methyl 1-(4-acetoxy-2-methylphenyl)-4-oxo-6-(4-nitrophenoxy)-methyl-1,4-dihydropyridine-3-carboxylate

: 149046-40-2
1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 2280 Torr; Ambient temperature;

Reference yield:

: 2835-99-6
4-amino-3-methylphenol

: 149046-40-2
1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) EtONa / 1.) EtOH, RT, 2 h, 2.) EtOH, reflux, overnight

2: 94 percent / SOCl₂ / 10 h / Heating

3: 83 percent / 4 h / 100 °C

4: 1.) SeO₂, 2.) charcoal / 1.) dioxane, 80 deg C, overnight, 2.) reflux, 1 h

5: 95 percent / SiO₂ / acetone / 2 h

6: 85 percent / NaBH₃CN, 10percent aq. HCl / 5 h / pH 2-3

7: 6 percent / potassium carbonate / acetone / 20 h / Heating

8: 83 percent / H₂ / 10percent Pd/C / methanol / 3 h / 2280 Torr / Ambient temperature

With hydrogenchloride; selenium(IV) oxide; thionyl chloride; hydrogen; sodium ethanolate; silica gel; sodium cyanoborohydride; potassium carbonate; pyrographite; palladium on activated charcoal; In methanol; acetone;

Reference yield:

: 181277-21-4
3-(dimethylaminomethine)-4-oxo-6-methyl-2-pyrone

: 149046-40-2
1-(4-Acetoxy-2-methyl-phenyl)-6-(4-amino-phenoxymethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) EtONa / 1.) EtOH, RT, 2 h, 2.) EtOH, reflux, overnight

2: 94 percent / SOCl₂ / 10 h / Heating

3: 83 percent / 4 h / 100 °C

4: 1.) SeO₂, 2.) charcoal / 1.) dioxane, 80 deg C, overnight, 2.) reflux, 1 h

5: 95 percent / SiO₂ / acetone / 2 h

6: 85 percent / NaBH₃CN, 10percent aq. HCl / 5 h / pH 2-3

7: 6 percent / potassium carbonate / acetone / 20 h / Heating

8: 83 percent / H₂ / 10percent Pd/C / methanol / 3 h / 2280 Torr / Ambient temperature

With hydrogenchloride; selenium(IV) oxide; thionyl chloride; hydrogen; sodium ethanolate; silica gel; sodium cyanoborohydride; potassium carbonate; pyrographite; palladium on activated charcoal; In methanol; acetone;