2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene

Base Information

• Chemical Name: 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene
• CAS No.: 1004960-33-1
• Molecular Formula: C₁₉H₂₈OSi₂
• Molecular Weight: 328.602
• Mol file: 1004960-33-1.mol

Synonyms:2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene

Chemical Property of 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene

There total 1 articles about 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trimethylsilyl-1,3-butadiyne (4526-06-1) + 1-iodo-2-(tert-butyldimethylsilyloxy)benzene (184368-89-6) → 2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene (1004960-33-1)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 50 ℃; for 6h;

DOI:10.1016/j.tet.2007.10.100

Reference yield: 72.0%

2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene (1004960-33-1) + benzyl azide (622-79-7) → 4-(benzofuran-2-yl)-1-benzyl-1H-1,2,3-triazole (1207638-31-0)

Guidance literature:

With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1217017

Reference yield: 70.0%

2-(4-trimethylsilyl-1,3-butadiyn-1-yl)-(tert-butyldimethylsilyl)oxybenzene (1004960-33-1) + (2-bromovinyl)trimethylsilane (41309-43-7) → 2-[(3E)-4-trimethylsilylbut-3-en-1-yn-1-yl]-1-benzofuran (1043252-45-4)

Guidance literature:

With methanol; potassium carbonate; silver(I) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1016/j.tet.2008.05.059

upstream raw materials:

trimethylsilyl-1,3-butadiyne

1-iodo-2-(tert-butyldimethylsilyloxy)benzene

Downstream raw materials:

2-ethynyl-1-benzofuran

2-[(4-nitrophenyl)ethynyl]-1-benzofuran

2-(2phenylethynyl)benzo[b]furan

2-[(3E)-4-trimethylsilylbut-3-en-1-yn-1-yl]-1-benzofuran