(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

Base Information

Chemical Name:(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate
CAS No.:1228189-83-0
Molecular Formula:C₁₇H₂₇O₃PS
Molecular Weight:342.439
Hs Code.:

Synonyms:(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

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Chemical Property of (1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

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Technology Process of (1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

There total 3 articles about (1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 19296-91-4
(1R,3S)-(1,2,2-trimethylcyclopentane-1,3-diyl)bis(methylene) di-p-tolylsulfonate

: 1228189-83-0
(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

Guidance literature:: (1R,3S)-(1,2,2-trimethylcyclopentane-1,3-diyl)bis(methylene) di-p-tolylsulfonate; With lithium bis(trimethylsilyl)phosphide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere;

With ethanol; In tetrahydrofuran; diethyl ether; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1039/b924983d

Reference yield:

: 124-83-4
D-(+)-camphoric acid

: 1228189-83-0
(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / Inert atmosphere

2.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere

3.1: lithium bis(trimethylsilyl)phosphide / tetrahydrofuran; diethyl ether / -78 - 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; lithium bis(trimethylsilyl)phosphide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b924983d

Reference yield:

: 68510-42-9
(+)-(1R,3S)-1,2,2-Trimethyl-1,3-bis(hydroxymethyl)cyclopentane

: 1228189-83-0
(1R,3S)-[1,2,2-trimethyl-3-(phosphinomethyl)cyclopentyl]methyl p-tolylsulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: lithium bis(trimethylsilyl)phosphide / tetrahydrofuran; diethyl ether / -78 - 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With lithium bis(trimethylsilyl)phosphide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b924983d